Study of the influence of autoclave sterilization on the properties of citrate functionalized iron oxide nanoparticles

Abstract Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are widely used in various areas of the biomedical field: for diagnosis (Magnetic Resonance Imaging), therapeutic applications (hyperthermia, nanovectorization). These require a good stability water and no aggregation SPIONs, with well-controlled physicochemical magnetic properties. In this work, SPIONs functionalized by citrate ligands synthesized one-step process aim producing stable water-dispersible nanoparticles well-crystallized spinel structure. Microwave technology is implemented to achieve objective given ease, speed reproducibility method. For their future use applications, sterilization these essential an autoclave treatment. The influence treatment on properties determined systematic characterization before after Transmission Electronic Microscopy, Dynamic Light Scattering, X-ray Diffraction, Fourier Transformed Infra-Red, ThermoGravimetric Analysis measurements.